2 edition of Susceptibility to in vitro oxidation of three low density lipoprotein (ldl) subfractions by copper ions found in the catalog.
Susceptibility to in vitro oxidation of three low density lipoprotein (ldl) subfractions by copper ions
Nikolaos K. Bounos
Written in English
Thesis (M.Sc.) - University of Surrey, 1997.
|Statement||Nikolaos K. Bounos.|
|Contributions||University of Surrey. School of Biological Sciences.|
Oxidation of Low-Density Lipoprotein by Iron at Lysosomal pH: Implications for Atherosclerosis Leanne Satchell and David S. Leake* School of Biological Sciences and Institute of Cardiovascular and Metabolic Research, Hopkins Building, Whiteknights, University of Reading, Reading RG6 6UB, U.K. The oxidative modification hypothesis of atherosclerosis predicts that low-density lipoprotein (LDL) oxidation is an early event in atherosclerosis. Therefore, inhibition of LDL oxidation might be an important step in preventing atherogensis (7,8). Humans protect themselves from (ROS), in part, by absorbing dietary antioxidants.
Familial combined hyperlipidemia (FCH) is a common heterogeneous lipid disorder with multigenic origin and a complex pattern of inheritance , and it is the most prevalent familial hyperlipemia and a major cause of 20–40% of myocardial infarctions .FCH is associated with high risk for coronary artery disease, which has been related to alterations in lipid profile as well as to the Author: Núria Puig, Inka Miñambres, Sonia Benítez, Pedro Gil, Margarida Grau-Agramunt, Andrea Rivas-Urbina. Human studies, however, have been less consistent in providing evidence for a role of vitamin E in preventing heart disease. Vitamin E supplements reduce ex vivo oxidizability of plasma LDLs but there is no correlation between ex vivo lipoprotein oxidizability and endogenous vitamin E levels in an unsupplemented population (24).Likewise, the few randomised double-blind, placebo-controlled.
Lipoprotein oxidation in the presence of 5 μm CuSO H 2 O was determined by measuring TBARS, conjugated dienes, and lysine content, exactly as described previously. Statistical analysis. The absence of differences between the two baseline placebo values was Cited by: Aim: To investigate the protective effect of high density lipoprotein 3 (HDL 3)on oxidized low density lipoprotein (ox-LDL)-induced apoptosis in RAW cells. Methods: RAW cells were exposed to 50 mg/L ox-LDL for various durations up to 48 h, and apoptosis was detected using Hoechst staining and flow cytometric analysis.
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We set out to investigate whether there was a relation between the ability of low-density lipoprotein (LDL) to resist oxidation in vitro and the severity of coronary atherosclerosis in man.
35 unselected young (mean [SD] age  years) male survivors of myocardial infarction underwent angiography, and LDL was isolated from their plasma Cited by: ELSEVIER Clinica Chimica Acta () Enhanced susceptibility of low-density lipoprotein to in vitro oxidation in type 1 and type 2 diabetic patients ~a Jean-Louis Beaudeux, Pierre-Jean Guillausseaub.llacqueline Peyneta, Franfoise Flouriea, Michel Assayagb, Dominique Tielmansb, Andr6 Warnetb, Franfois Rousseleta aLaboratoire Central de Biochimie, [email protected] Lariboisibre, 2 Cited by: Furthermore, one study found that the addition of a moderate amount of dietary cholesterol to a reduced fat diet rich in PUFA or SF increased in vitro susceptibility of low density lipoprotein.
We have studied in vitro susceptibility to the oxidation of LDL isolated from the plasma of three groups of diabetics and measured the total fatty acids, malondialdehyde (MDA), and α-tocopherol in native and oxidized LDL. Subjects and methods SubjectsCited by: 5. Dietary habits affect the susceptibility of low-density lipoprotein to oxidation Article (PDF Available) in European Journal of Clinical Nutrition 53(10) November with 91 Reads.
Background. Oxidative modification of low density lipoproteins (LDL) is recognized as one of the major processes involved in atherogenesis. The in vitro standardized measurement of LDL oxidative susceptibility could thus be of clinical by: Abstract.
It is now recognized that oxidation of low-density lipoprotein (LDL) is a key event in the development of atherosclerosis ().In vivo, oxidation is believed to occur primarily in the arterial : Jane McEneny, Ian S.
Young. Background. The fact that low density lipoprotein (LDL)1 is extremely susceptible to oxidative damage has been known for some time (1, 2), but until quite recently this was primarily a nuisance for the student of lipoprotein now appears that oxidation of LDL plays a significant role in atherogenesis.
Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein which transport all fat molecules around the body in the extracellular water. These groups, from least dense to most dense, are chylomicrons (aka ULDL by the overall density naming convention), very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein and high-density.
The lipids of high density lipoproteins (HDL) are initially oxidized in preference to those in low density lipoprotein when human plasma is exposed to aqueous peroxyl radicals.
In this work we report on the relative susceptibility of HDL protein and lipid to oxidation and on the role HDL’s α-tocopherol (α-TOH) plays in modulating protein. This study was designed to determine the in vitro effects of nicotine and its metabolite cotinine on the susceptibility of LDL to oxidation and hemoglobin glycosylation.
Three different concentrations of each one (10, 15, 25 µg/ ml) were by: 3. Figure 4 Native human HDL-cholesterol and apoA-I-containing reconstituted HDL-cholesterol inhibit the increase in E-selectin expression induced by C-reactive cent inhibitions were calculated from mean levels of expression of E-selectin before and after exposure to HDL-cholesterol and/or C-reactive protein (mean expression after stimulation by C-reactive protein=%).Cited by: The etiopathogenesis of endometriosis still remains unknown.
Recent data provide new valuable information concerning the role of oxidative stress in the pathophysiology of the disease. It has been proved that levels of different lipid peroxidation end products are increased in both peritoneal fluid (PF) and serum of endometriotic patients. We assessed the concentration of oxidized low-density Cited by: 8.
Seasonal variation in Low Density Lipoprotein oxidation and antioxidant status Susceptibilty of LDL to oxidation and atherosclerosis LDL oxidation and risk of coronary atherosclerosis Oxidation of LDL and risk of peripheral atherosclerosis Autoantibodies against oxidized LDL Author: Lucy van de Vijver.
Estrogen decreases low density lipoprotein (LDL) particle size, and smaller LDL particles are associated with coronary atherosclerosis. To understand the metabolic basis for this change, we studied the effect of oral 17β-estradiol (2 mg/day) on apolipoprotein B (apoB) metabolism, in eight healthy postmenopausal by: The oxidative modification hypothesis of atherosclerosis, which assigns to oxidized low-density lipoproteins (LDLs) a crucial role in atherosclerosis initiation and progression, is still debated.
This review examines the role played by oxidized LDLs in atherogenesis taking into account data derived by studies based on molecular and clinical by: oxidation in vitro.
Compared with off soy values, lag phases of LDL oxidation curves were prolonged by a mean of 20 min (P suscepti-bility to oxidation.
The results suggest that intake of soy-derived antioxidants, such as genistein and daidzein, may provide protection against oxidative Cited by: To clarify whether supplementation of vitamin E can alter the low density lipoprotein (LDL) oxidation properties and thereby affect endothelial cell function and prostacyclin production in smokers Cited by: 9.
Very-low-density lipoproteins (VLDL) were isolated, under the same density conditions by centrifugation for 18 hours atx g. Centrifugation was done atx g for 20 and 48 hours to isolate low-density lipoprotein (LDL, d = g/ml) and high.
Inhibition of Human Low-Density Lipoprotein Oxidation In Vitro by Maharishi Ayur-Veda Herbal Mixtures [MAK-4, MAK-5, MA, and Maharishi Coffee Substitute] 4. In Vitro and In Vivo Inhibition of Microsomal Lipid Peroxidation by MA 5. Protective Effects of MAK-4 and MAK-5 on Adriamycin-Induced Microsomal Lipid Peroxidation and Mortality 6.
As peroxynitrite is implicated as an oxidant for low-density lipoprotein (LDL) in atherogenesis, we investigated this process using reagent peroxynitrite (ONOO-) and 3-morpholinosydnonimine (SIN-1, which produces peroxynitrite via generation of NO• and O2•-).
LDL oxidation was assessed by the consumption of ubiquinol (CoQ10H2) and α-tocopherol (α-TOH), the accumulation of cholesteryl Cited by: The Figure shows the selection of participants who did not have metabolic syndrome at year 15 () for whom fresh frozen blood samples were available at year 15 for measuring plasma oxidized low-density lipoprotein and for whom all data were available at years 15 and 20 ().
a Participants could be excluded for more than 1 Cited by: Antioxidants are compounds that inhibit oxidation. Oxidation is a chemical reaction that can produce free radicals, thereby leading to chain reactions that may damage the cells of organisms.
Antioxidants such as thiols or ascorbic acid (vitamin C) terminate these chain reactions. To balance the oxidative stress, plants and animals maintain complex systems of overlapping antioxidants, such as.